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KMID : 0358419760190100725
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Korean Journal of Obstetrics and Gynecology
1976 Volume.19 No. 10 p.725 ~ p.732
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Mid-trimester abortion induced by extra-amniotic administration of prostaglandin F2a
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정순오/Chung SO
홍영범/곽현모/Hong YJ/Kwak HM
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Abstract
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Prostagladin F2a was injected extra-amniotically through foley catheter in 26 patients between 15 and 31 weeks gestation in the dosage schedule. Mid-trimester abortion was successfully induced in 26 patients by administration of extra-amniotic PgF2a The mean abortion time for the successful induction was 19.65 hrs. Abortion was successfully induced in 77% of patients within 24 hrs and in 100% within 48 hrs. Multiparous patients aborted somewhat faster than nulliparous patients, but the difference was not sighnificant . Among the 26 successful inductions 20 patients aborted in 24 hrs. the most frequently encountered side effect of extra-amniotic PgF2a administration was a gastriontestinal disturbances-nausea, vomitting and diarrhea. A temperature elevation was also common, which returned to normal within a few hours of last dose of the drug. These side effects were in general well tolerated by the patients and never required therapy or termination. In a single patients surgical intervention was required to remove the placenta. In one patients the placenta was removed by sponge forceps and in one patients the placenta was removed mannually . There was an estimated blood loss exceeding 250ml in one patients but transfusion was not required. Indication of extraamniotic PgF2a administration was intrauterine fetal death in 8 patients and psychosocial problem in 8 patients. the mean pitocin augmentation time for the successful induction was 3.78hours. Multiparous patients aborted somewhat faster than nulliparous patients in pitocin augmentation time but the difference was not sighnificantly. The mean total dosage of PgF2a was 5529ug. The mid-trimester abortion with extra-amniotic administration of PgF2a appears to offer a valid alternative to the presently available techniques, with a rapid abortion time high success rate, low incidence of side effects and complications.
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